Yes, gynecomastia can cause psychological distress, especially if it is accompanied by feelings of self-consciousness, embarrassment, or anxiety. For some men, the enlarged breast tissue can be a source of shame and affect their self-esteem. They may avoid activities that require them to remove their shirt or wear tight-fitting clothing. This can lead to social isolation, depression, and anxiety. In severe cases, gynecomastia can affect a person’s quality of life and lead to mental health issues. Seeking treatment for gynecomastia, whether through medication or surgery, can help alleviate the psychological distress associated with the condition.