Yes, gynecomastia can come back after treatment. The recurrence of gynecomastia may occur if the underlying cause of the condition is not addressed, or if the patient resumes taking medications that can cause gynecomastia. Additionally, weight gain or the use of anabolic steroids may cause a recurrence of gynecomastia. Therefore, it is important for patients to continue to follow-up with their healthcare provider and make any necessary lifestyle changes to minimize the risk of a recurrence. In some cases, additional treatment may be needed to address recurrent gynecomastia.